Endocrine Abstracts

Introduction: Follicle stimulating hormone receptors (FSHR) are physiologically expressed in gonads. FSHR are also expressed in gonadal cancers, but nothing is known on FSHR appearance in non-gonadal endocrine tumors. The present paper reports on the immunohistochemical detection of FSHR in pituitary, thyroid, adrenal and neuroendocrine tumors (NET).Materials and methods: The study included samples of 80 endocrine tumors (28 pituitary adenomas, 7 thyroid...

Endostatin, a cleaved fragment of collagen XVIII, is a potent endogenous angiogenesis inhibitor. Elevated serum endostatin levels have been recently reported in patients with various types of neoplasms. The purpose of our study was to evaluate serum concentrations of endostatin in patients harbouring various types of pituitary adenomas and to examine the relationship of serum endostatin levels to circulating vascular endothelial growth factor (VEGF) levels. Preoperative serum ...

Clinically non-functioning pituitary adenomas (CNFPA) represent a heterogenous group of tumors. Most of CNFPA are aggressive, usually diagnosed relatively late and surgery often fails to achieve the complete excision of tumor and the recurrence rate is high. About 80% of CNFPA are characterized by intense expression of somatostatin receptors (SSTR) inspiring use of somatostatin analogs (SSTa) in the medical cure of CNFPA. Scintigraphy with visualization of SSTR2 expression and...